The aesthetic medicine landscape is shifting from a pursuit of ‘permanence’ to ‘sustainability.’ This article explores the rise of biodegradable fillers, like hyaluronic acid, PLLA, and PCL, which are safely metabolized by the body, offering a reversible and low-risk alternative to older, non-biodegradable materials such as silicone and PMMA. Discover the new metrics for evaluating fillers: reversibility, body load, and stimulation versus filling. Ultimately, the choice lies between a high-risk gamble for ‘permanent’ results and a responsible, sustainable approach to beauty.